2001•Zhongguo renshougonghuanbing zazhiRequires access

STUDY ON THE DETECTION OF SERUM ANTIBODY IN SERA OF PATIENTS WITH SCHISTOSOMIASIS JAPONICA BY COLLOIDAL GOLD SEA-DIPSTICK

Gan Yan

Abstract

Aim To develop an accurate,rapid,simple and applicable assay for the diagmosis of Schistosomiasis japonica.Method A time-saving,reliable colloidal gold SEA-dipstik assay was applied to detect serum antibody of schistosomiasis japonica.Results All of 28 sera from patients with accute schistosomiasis showed positive reaction while 289 of 297(97.31%) sera from chronic schistosomiasis were positive by SEA-dipstick assay.1 of 518(0.19%) sera from normal population gave false positive reaction 14 of 573(2.4%) cases of various other parasitic diseases,including paragonimiasis,clonorchiasis,cysticercosis,and trichinellosis,showed cross reaction.SEA-dispstick assay showed similar sensivity and higher specificity as parallel testing by Dot-LISA (P005).Conclusion Colloidal gold SEA-dipstick assay is not only rapid and simple,but also sensitive adn specific for the detection of serum antibody of schistosomiasis japonica.It will be a practical immunological assay for the diagnosis of schistosomiasis in the future.

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Available abstract

Key concepts: Dipstick, Clonorchiasis, Schistosomiasis, SCHISTOSOMIASIS JAPONICA, Paragonimiasis, Antibody, Cysticercosis, Gold standard (test)