Serum Levels of Interleukin 10 and Interleukin 18 in Patients with Posthepatitic Cirrhosis and Their Clinic Sgnificance

Objective To explore the relationship between serum interlukin-10(IL-10)、interlukin-18(IL-18)levels and pathogenesis in patients with posthepatitic cirrhosis.Methods The serum levels of IL-10 and IL-18 were detected by ELISA respectively in 62 patients with post-hepatitic cirrhosis and 20 controls.The 62 patients were divided into three groups as A,B and C according the Child-pugh scores.Results 1.The levels of IL-18 in groups A、B、C were all higher than those in controls and increased with worsening of child score(P0.01);The levels of IL-10 in group A were littele higher than those in controls(P0.05),but significantly higher in group A than those in groups B and C (P0.05～0.01),the levels in C groups were much lower than those in B groups(P0.01).2.patients with ascites had higher levels of IL-18 than patients without ascites (P0.05),however,had lower levels of IL-10.3 The levels of IL-10 in patient were correlated with PTA and albumin concentrations and inversely correlated with serum bilirubin concentrations.The levels of IL-18 in patiens were correlated with serum bilirubin concentrations and inversely correlated with PTA and albumin.4 The levels of IL-10 were inverslycorrelated with IL-18(R=-0.51,P0.01).Conclusion IL-18 and IL-10 may involve in the pathogenetic process of post-hepatitic cirrosis and have significant correlations.The levels of IL-18、IL-10 reflect degree of hepatocyte damage to some extent.