Efficacy of Oxcarbazepine or Lamotrigine combined with Valproic acid for treatment of traumatic epilepsy recurrence

Objective To compare the effect of Oxcarbazepine or lamotrigine joint treatment on traumatic epilepsy relapse after Valproic acid given alone.Methods 3 months before the combine treatment of seizure frequency was as the control,and after 12 months of joint treatment,the efficacy,adverse effects and safety was compared respectively.Results After application of Oxcarbazepine or Lamotrigine combined Valproic acid treatment for 12 months,the patient's seizure frequency decreased significantly compared with before.Seizure frequency reduction of ≥ 50% of patients reached 89.2% and 89.7% separately,and statistically significant difference was observed before and after joint treatment(P0.05).There was also significant difference between two groups of Oxcarbazepine or Lamotrigine combined Valproic acid treatment(P0.05).The adverse events of Oxcarbazepine combined Valproic acid treatment was 19.3%,while Lamotrigine combined Valproic acid treatment adverse events was 9.1%,difference was significant.Conclusion Oxcarbazepine or Lamotrigine combined Valproic acid treatment of traumatic epilepsy recurrence is effective,and the side effects of combination of Lamotrigine and Valproic acid was lighter.