Research on the Change of Aplastic Anemia Patients Serum IL-2,TNF-α,IFN-γ and Peripheral Blood T Lymphocyte Subsets

Objective:To study the correlation between changes of serum IL-2,IL-8,TNF-α,IFN-g and peripheral blood T lymphocyte subsets of aplastic anemia(AA) patients and disease severity.Methods:40 AA patients were selected by enzyme linked immunosorbent method(ELISA) screening in our hospital,including 20 acute patients(AAA) and 20 chronic(CAA) patients.Another 20 healthy people were randomly selected.Changes of serum IL-2,IL-8,TNF-α,IFN-g and peripheral blood T lymphocyte subsets of the 60 cases were monitored and compared.Results:In the AA group,detection results of each cell factor CD3+,CD4+,CD4+/CD8+ of AAA patients fluctuated greater than that of CAA patients.The serum levels of IL-2,IL-8,TNF-α,IFN-g of AA patients was obviously higher than the average levels of health persons.The levels of CD4+,CD4+ /CD8+ of AA patients were significantly lower than the average levels of health persons.But the changes of CD3+ the difference had no statistical significance.CD8+ levels of AA patients were significantly higher than those in the control group,with was statistical difference,P0.05.Conclusion:Patients with aplastic anemia had cellular immune function obstacle and humoral immunity mechanism anomaly as well,and the changing regulations were positively correlated with the severity and acute degree of disease.