Effect of Electroacupuncture on Changes of Glutamic Acid Level of Hippocampal Tissue with Alzheimer's Disease in Rats

Objective To observe the effect of electroacupuncture on the glutamic acid level in the hippocampus of rats with Alzheimer's disease(AD).Methods SD rats were randomly divided into 4 groups: the normal group,sham-operated group,model group,EA group.Bilateral hippocampus were injected condensed Aβ25-35 to be prepared for rat model of AD.Electro-acupuncture group were selected bilateral Shenshu points,bilateral Neiguan points and Dazhui points for 6 weeks,then connected G6805-Ⅱ type of electroacupuncture therapeutic apparatus.We selected the frequence of 2 Hz continuous wave and the intensity of 1mA,last 20min,every day one times,6 times a week,a total of two weeks treatment.We used used spectrophotometric method to detect the changes of Glu in each group.And make a further analysis on the effect of electro-acupuncture's intervention to Glu.Results Glu of model group's hippocampus were significantly higher than the sham group,and there was a significant difference(P0.01);Compared with model group,Glu of EA group's hippocampus decreased significantly(P0.05).Conclusions Its mecha-nism may be achieved through the following means: Reduce Glu neurotoxicity,protect the hippocampal neurons;so as to improve AD rats learning and memory capacity.