Clinical observation of different dose of mifepristone in treating uterine leiomyoma

Objective To evaluate the response of uterine leiomyoma to three different daily dosages of mifepristone. Methods Forty nine patients with uterine leiomyoma were divided into three groups randomly. Twenty one patients were treated with 10mg of mifepristone daily, sixteen patients with 12.5mg daily and twelve patients with 25mg daily for 3 months, beginning on day 2 of the menstrual cycle. Volume changes of leiomyoma and uterus were measured with ultrasonography before treatment and monthly during the course of therapy. Blood samples for hemoglobin, liver and renal function were obtained monthly. Results Ovarine acyclicity was induced in 3 groups of patients given different daily dose of mifepristone and clinical symptoms improved obviously. After 3 months of mifepristone treatment, the leiomyoma volume decreased to 39.8% of baseline in group A, 40.5% in group B and 44.4% in group C. There was no significant difference in the three treatment groups.Conclusion Mifepristone is a practical and hopeful drug in treating uterine leiomyoma, 10 mg of mifepristone daily is considered to be a more ideal dosage for treatment.