Clinical observation of uterine leiomyoma treated with small dose of mifepristone

Objective To observe the result of uterine leiomyoma treated with small dose of mifepristone. Methods Twenty - five patients with uterine leiomyoma , who was diagnosed by vagninal examination and ultra-sonography were treated with 12.5 mg of mifepriston daily and lasted for 3 monthes , 5 of them lasted for 6 mon-thes. Results After taking mifepristone for 3 monthes, the volume of leiomyoma reduced 63. 8% (P0. 01)and after taking mifepristone for 6 monthes, the volume of leiomyoma reduced 65. 2%. There was no significant difference between the two treated groups (P0. 05). During treatment amenorrhea occurred and after treatment the symptoms of dysmenorrhea, hypermenorrhea, irregular uterine bleeding were improved obviously in all patients. Conclution Takeing small dose of mifepristone daily is considered to be a more ideal methods to treat u-terine leiomyoma in young patients with symptomatic leiomyoma (uterine sizethat of 12 weeks of gestation) and perimenopausal patients. The best course of treatment is 3 monthes.