Relationship between Oxygen Free Radicals and Congestive Heart Failure with Multiple Organ Function Failure in Elderly as Well as the Effects of Drugs Intervention

Objective To study the effects of Ginkgo Leaf Extract and Dipyridamole in treating congestive heart failure(CHF) with multiple organ function failure(MOF)in elderly,and its effect on anti-oxygen free radicals.Methods Choose fifty people as normal con- trol group.Seventy-eight patients with CHF with MOF in ehlerly were randomly divided into three groups.Standard therapy group,diuretics and angiotensin-converting enzyme inhibitor(ACEI),Ginkgo Leaf Extract and Dipyridamole group ,Compound Danshen group.After four weeks,treatment,the changes of superoxide dismutase(SOD),malondialdehyhe(MDA),lipid peroxidr(LPO)and glutathione peroxidase (GSH-PX)were detected in the three groups,patients.Results①Before treatment the levels of SOD and GSH-PX in standard therapy group,Ginkgo Leaf Extract and Dipyridamole group and compound Danshen group were significantly lower compared with the normal control group(P0.01),while the levels of MDA and LPO were significantly higher(P0.01);②Compared with pre-treatment,after treatment the levels of SOD and GSH-PX in Ginkgo Leaf Extract and Dipyridamole group and compound Danshen group were significantly higher(P0. 01),while the levels of MDA and LPO were significantly lower(P0.01);③The changes of SOD,GSH-PX,MDA and LPO in the standard therapy group did not reach statistical significance(P0.05);④After treatment,the levels of SOD and GSH-PX in Ginkgo Leaf Extract and Dipyridamole group were significantly higher compared with compoud Danshen group and standard therapy group(P0.01),while the lev- els of MDA and LPO were significantly lower(P0.01);⑤In compound Danshen group,after treatment the levels of SOD and GSH-PX were significantly higher compared with standard therapy group(P0.05),while the levels of MDA and LPO were significantly lower(P0.05). Conclusion Anti-oxidant action of Ginkgo Leaf Extract anti Dipyridamole was significant.Ginkgo Leaf Extract and Dipyridamole plays a crit- ical role in intercepting the occurrence and development of MOF and reducing the mortality.