Comparative study on the prevention of nausea and vomiting postoperatively due to use of morphine.

Objective To compare the prophylactic efficacy and side effects of ondansetron and droperidol on nausea and vomiting in postoperative patient using postoperative patient-controlled epidural analgesia (PCEA) with Morphine. Methods 96 ASA I～II patients scheduled for abdominohystcrectomy under epidural anesthesia were randomly divided into two groups: Ondansetron group (n=48) and droperidol group (n=48). Ondansetron group was given 8mg of ondansetron, droperidol group 5mg of droperidol, which were mixed with PCEA, and then injected into epidural cavity.BP, RR, ECG, SpO2 were monitored continuously after operation. Efficacy of analgesia was assessed by VAS scores. The incidences of postoperative nausea and vomiting(PONV) was observed within 48h after operantion. Other side effects such as drowsiness, extrapyramidal reaction were also observed. Results There was no significant difference in the mean VAS score between ondansetron group and droperidol group after operation, There was a significantly different incidence in PONV in the two groups which was lower in ondansetron group than in droperidol group(P0.05). Conclusion Ondansetron can provide better effect and lower side effects than that of droperidol in prevention of PONV in PCEA with morphine after operation.