THE ANTIEMETIC EFFECTIVENESS OF DROPERIDOL AND ONDANSETRON DURING MORPHINE PATIENT CONTROLLED ANALGESIA

This prospective, double blind study examined the antiemetic effectiveness of ondansetron and the addition of droperidol to a morphine solution for use in patient controlled analgesia. 80 patients,ASAⅠ～Ⅱ,undergoes elective abdominal surgery under general anesthesia were allocated randomly to receive patient controlled analgesia with morphine alone (2mg/ml)(GroupⅠ), a mixture of morphine and either droperidol 0.05mg/ml (GroupⅡ) or droperidol 0.125mg/ml (Group Ⅲ) and morphine alone as before plus 4mg ondansetron administered intravenously at induction of anesthesia (Group Ⅳ). The scores for nausea, vomiting, pain and sedation and visual analogue scale(VAS)were made at 4, 8, 12, 24, 48 h postoperatively. There was no difference between the groups at any time in the amount of morphine consumed or in pain scores.The incidence of nausea and vomiting decreased from 77.7% and 50% in the morphine only group to 55% and 35% in the group Ⅱ, 42.1% and 21.2% in the group Ⅲ and 40% and 20% in ondansetron group ( P 0.05) respectively. The droperidol groups has significantly higher sedation scores than the other groups ( P 0.01).We conclude that droperidol added to morphine and ondansetron reduce postoperative nausea and vomiting associated with patient controlled analgesia and ondansetron is superior to droperidol when used for morphine patient controlled analgsia and causes less sedation.