2010•Zhongguo yiyuan ganranxue zazhiRequires access
Susceptibility to cefoperazone/sulbactam of multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa.
Yishan Huang, Fang Li, SU Zhong-long, Zhu Xing-chun, Lin Fang, He Ying, Huo Ya-ping
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Abstract
OBJECTIVE To detect metallo-β-lactamases(MBLs) produced by multidrug-resistant Acinetobacter baumannii(MDR-AB) and multidrug resistant Pseudomonas aeruginosa(MDR-PA) in our hospital and their resistance to cefoperazone/sulbactam.METHODS VITEK-32,GNS-132 system,routine test were used to detect non-duplicating A.baumannii(42 strains) and P.aeruginosa(95 strains),while Etest used to detect MBLs and K-B method to detect drug sensitivity to cefoperazone/sulbactam and polymyxin E.The sensitivity of two different drug-resistant phenotypes to cefoperazone/sulbactam was and analyzed.RESULTS The imipenem resistance rate of A.baumannii and P.aeruginosa was 66.7% and 31.6%,respectively.MRD-AB and MRD-PA had more MBLs strains.The sensitivity of imipenem-resistant van-producing MBLs strains to cefoperazone/sulbactam statistically was without significant difference,while that with MBLs was with significant difference(P0.05).CONCLUSIONS The sensitivity to cefoperazone/sulbactam of MDR-AB is higher than that of MDR-PA.Cefoperazone/sulbactam can be choose to treat MDR-AB with imipenem resistance MDR-PA with imipenem resistance especially producing metallo β-lactamases,can be treated with polymyxin E or its combination.