Effects of Resveratrol on Learning,Memory and Brain Antioxidant Abilities in D-Galactose-Induced Aging Mice

Objective: To investigate the effects of resveratrol(Res) on learning, memory and brain antioxidant capacities in D-galactose-induced aging mice. Methods: Fifty ICR mice were randomly divided into five groups, designated as normal control, model, resveratrol low-dose, moderate-dose and high-dose groups. The normal control group was given normal saline by gavage, and all other groups were given D-galactose solution by neck back subcutaneous injection at the daily dose of 120 mg/(kg·d) for 8 consecutive weeks. At the same time, Res-treated mice were administered Res by gavage at the daily doses of 25, 50 and 100 mg/(kg·d) body weight per day, respectively. The learning and memory abilities of mice were determined by Morris water maze test. Superoxide dismutase(SOD), total antioxidant capacity(T-AOC) and malondialdehyde(MDA) in the brain of mice were determined at the end of 12 h of fasting after the last administration. Results: Res could reduce the time mice spent on finding platform(P 0.01), improve the swimming speed(P 0.01) and the number of times mice crossed the platform(P 0.01) in Morris water maze test, increase SOD(P 0.01) and T-AOC activities(P 0.05) and decrease the content of MDA(P 0.01) in brain tissue. Conclusion: Res can ameliorate the degeneration of learning and memory abilities in D-galactose-induced aging mice, improve brain antioxidant abilities and thus delay brain aging.