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2009•Zhongguo laonianxue zazhiRequires access

Study on the different dosages of D-galactose inducing brain aging mouse model

Song Li

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Abstract

Objective To explore the effect of different dosages of D-galactose (D-gal) inducing brain aging mouse model. Methods Three-month-old mice were randomly divided into 75,120,150,1000 mg/kg D-gal groups and control group. The mice of D-gal groups received subcutaneous injection of D-gal once daily. The mice of control group were administered with saline. After 8 weeks,the ethology and enzyme of brain were detected. Results Compared with control group,the cognitive function and the content of superoxidase dismutase (SOD),malondialdehyde (MDA) and catalase (CAT) of the mice treated with D-gal were changed in some extent. Conclusions The various dosage of D-gal injection for 8 weeks can change the indicators of brain but there are different effects on indicators among dosages.

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What this paper is about

Objective To explore the effect of different dosages of D-galactose (D-gal) inducing brain aging mouse model. Methods Three-month-old mice were randomly divided into 75,120,150,1000 mg/kg D-gal groups and control group. The mice of D-gal groups received subcutaneous injection of D-gal once daily. The mice of control group were administered with saline. After 8 weeks,the ethology and enzyme of brain were detected. Results Compared with control group,the cognitive function and the content of superoxidase dismutase (SOD),malondialdehyde (MDA) and catalase (CAT) of the mice treated with D-gal were changed in some extent. Conclusions The various dosage of D-gal injection for 8 weeks can change the indicators of brain but there are different effects on indicators among dosages.

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Available abstract

Objective To explore the effect of different dosages of D-galactose (D-gal) inducing brain aging mouse model. Methods Three-month-old mice were randomly divided into 75,120,150,1000 mg/kg D-gal groups and control group. The mice of D-gal groups received subcutaneous injection of D-gal once daily. The mice of control group were administered with saline. After 8 weeks,the ethology and enzyme of brain were detected. Results Compared with control group,the cognitive function and the content of superoxidase dismutase (SOD),malondialdehyde (MDA) and catalase (CAT) of the mice treated with D-gal were changed in some extent. Conclusions The various dosage of D-gal injection for 8 weeks can change the indicators of brain but there are different effects on indicators among dosages.

Key concepts: Dose, Malondialdehyde, Catalase, Saline, Subcutaneous injection, Galactose, Dismutase, Endocrinology

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