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EXPRESSIONS AND CLINICAL SIGNIFICANCE OF P53,P16 AND Bcl-2 IN NON-SMALL CELL LUNG CANCER

C Zhang

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Abstract

Objective To explore the expressions of P53,P16 and Bcl-2 in non-small cell lung cancer(NSLC) and their clinical significance. Methods Immunohistochemical technique was used to detect the expressions of P53,P16 and Bcl-2 in cancer tissue of 60 primary NSCLC patients,and 18 normal tissue samples that 5 cm away from the border of the cancer. ResultsThe differences of expressions of P53,P16 and Bcl-2 between cancer tissue and paraneoplastic tissue were significant(Hc=10.003-14.783,P0.01),The expressions of P53 and P16 were related to differentiation of the cancer(Hc=15.119,19.078;P0.01),and that of Bcl-2 was related to differentiation,TNM stage and lymphatic metastasis(Hc=16.271,13.205;u=2.849;P0.01).The expression of P53 was negatively correlated with P16(rs=-0.437,P0.01). Conclusion Unbalance of the expressions of P53,P16 and Bcl-2 is closely associated with the occurrence and development of non-small cell lung cancer.

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Objective To explore the expressions of P53,P16 and Bcl-2 in non-small cell lung cancer(NSLC) and their clinical significance. Methods Immunohistochemical technique was used to detect the expressions of P53,P16 and Bcl-2 in cancer tissue of 60 primary NSCLC patients,and 18 normal tissue samples that 5 cm away from the border of the cancer. ResultsThe differences of expressions of P53,P16 and Bcl-2 between cancer tissue and paraneoplastic tissue were significant(Hc=10.003-14.783,P0.01),The expressions of P53 and P16 were related to differentiation of the cancer(Hc=15.119,19.078;P0.01),and that of Bcl-2 was related to differentiation,TNM stage and lymphatic metastasis(Hc=16.271,13.205;u=2.849;P0.01).The expression of P53 was negatively correlated with P16(rs=-0.437,P0.01). Conclusion Unbalance of the expressions of P53,P16 and Bcl-2 is closely associated with the occurrence and development of non-small cell lung cancer.

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Available abstract

Objective To explore the expressions of P53,P16 and Bcl-2 in non-small cell lung cancer(NSLC) and their clinical significance. Methods Immunohistochemical technique was used to detect the expressions of P53,P16 and Bcl-2 in cancer tissue of 60 primary NSCLC patients,and 18 normal tissue samples that 5 cm away from the border of the cancer. ResultsThe differences of expressions of P53,P16 and Bcl-2 between cancer tissue and paraneoplastic tissue were significant(Hc=10.003-14.783,P0.01),The expressions of P53 and P16 were related to differentiation of the cancer(Hc=15.119,19.078;P0.01),and that of Bcl-2 was related to differentiation,TNM stage and lymphatic metastasis(Hc=16.271,13.205;u=2.849;P0.01).The expression of P53 was negatively correlated with P16(rs=-0.437,P0.01). Conclusion Unbalance of the expressions of P53,P16 and Bcl-2 is closely associated with the occurrence and development of non-small cell lung cancer.

Key concepts: Immunohistochemistry, Lung cancer, Clinical significance, Medicine, Stage (stratigraphy), Cancer, Cancer research, Metastasis

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