Polymorphism of the fatty acid-binding protein 2 gene in patients with coronary heart disease

Objective To investigate the association between the polymorphism of codon-54 of the fatty acid binding protein gene(FABP2) and patients with coronary heart disease. Methods The Ala54Thr variation of FABP2 was detected by PCR and Hae-II digestion in 176 Chinese subjects, including 86 cases of coronary heart disease and 90 cases of normal controls. Results (1) The polymorphism restriction site of codon-54 of FABP2 gene results in the substitution of threonine(Thr) for alanine(Ala). (2) The frequence of genotype Ala54/Thr54 and Thr54/Thr54 significiantly increased in the coronary heart disease as compared with that in healthy subjects(P=0.017). (3) The odds ratio of FABP2 genotype Ala54/Thr54 and Thr54/Thr54 for the patients with coronary heart disease was 2.16(95% confidence intervals is 1.03-3.54). Conclusion (1)The sample is in existence of FABP2 polymorphism. (2)FABP2 gene polymorphism seems to be significantly associated with coronary heart disease. (3)FABP2 polymorphism may have a certain contribution to the abnormity of lipoprotein metabolism in coronary heart disease individuals.