The short-term prognostic value of MMP-9 in patients with acute coronary syndromes

Objective To study the serum levels of matrix metalloproteinase-9(MMP-9),high senstivity C-reactive protein(hs-CRP) and cardiac troponin I(cTnI)in patients with acute coronary syndrome(ACS)and its short-term prognostic value.Methods The study population included 60 patients with ACS,30 patients with stable angina pectoris(SAP) and 30 healthy adults who attended a routine health check(control group).With the pinpoint of the MMP-930ng/ml,the two groups were observed of the rate of cardiac events.Results Serum levels of MMP-9 were significiently higher in the ACS group(30.33±14.00)ng/ml than those in the SAP group(2.72±0.98)ng/ml and the control group(2.84±0.82)ng/ml(P0.05).The SAP group had no difference with the control group(P0.05).Serum levels of hs-CRP were significently higher in the ACS group(8.05±2.48)mg/L than those in the SAP group(2.27±0.84)mg/L and the control group(2.17±0.91)mg/L(P0.05).The SAP group had no difference with the control group(P0.05).Serum levels of cTnI were significiently higher in the ACS group(0.78±0.21)ng/ml than those in the SAP group(0.29±0.09)ng/ml and the control group(0.29±0.08)ng/ml(P0.05).The SAP group had no difference with the control group(P0.05).In the three-month follow-up,37 patients with higher MMP-9 in the 60 ACS had 18 cardiac events.The ratio of cardiac events were higher than that in the control group(P0.05).Conclusion The MMP-9 plays important roles in the prognosis in patients with ACS.MMP-9 could be used as an indicator of risk stratification.The united detection of MMP-9,hs-CRP and cTnI is more meaningful in ACS patients.