Inhibition of endostar combined with paclitaxel and cisplatin on the proliferation of esophageal cancer cells

Objective To investigate the anti-tumor effects of recombinant human endostatin(endostar) combined with paclitaxel and cisplatin(TP) on esophegeal carcinoma cells.Methods Eca-109 esophageal carcinoma cell lines were subcultured until cells in logarithmic phase,then the rat models with esophageal carcinoma cells Eca-109 xenografts were constructed,the anti-tumoral effects of control group(saline),endostar group,TP group,endostar combined with TP group were observed.The tumor weigh and volume were measured,the inhibition rate of tumor growth curve was calculated,the cell apoptotic rate was detected by flow cytometry,and the expressions of apoptotic protein Bax and Bcl-2 were detected by immunohistochemistry staining.Results Endostar combined with TP can obviously inhibit the growth of transplanted tumor,and tumor size and weight were lower,and the apoptotic rate was higher than those in the other groups(P 0.05).The expression of Bcl-2 was lower,while Bax was higher in endostar combined with TP group than those in the other groups(P 0.05).Conclusion Endostar combined with TP could significantly inhibit the growth of esophageal carcinoma cells and tumor,which was better than the application of TP.