2010•Hebei yiyaoRequires access
Study on the action mechanism of protective effects of curcumin on kidney of experimental diabetic rats
Yanjun Su
Open publisher page 1 citations
Abstract
Objective To investigate the action mechanism of protective effects of curcumin on kidney of experimental diabetic rats,by observing the effects of curcumin on the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in kidney of experimental diabetic rats.Methods The rats were randomly divided into normal control group( group A),diabetes group(group B) and curcumin treatment group (group C),The rat models of diabetes were established by intraperitoneal injection with curcumin 60mg/kg.The rats in curcumin treatment group were given curcumin 30mg·kg-1·d-1 intraperitoneally.The UAER,Ccr and the ratio of kidney weight/body weight were detected after 3-week and 6-week treatment,and the expressions of MMP-2,TIMP-2,FN and collagen Ⅳ were measured by immunohistological staining.Results The UAER,Ccr and the ratio of kidney weight/body in group C were significantly lower than those in group B (P0.05 or P0.01).As composed with those in group C,the protein expressions of TIMP-2,FN and collagen Ⅳ were significantly increased in glomeruli of the rats in group B(P0.05 or P0.01).The expression of MMP-2 was significantly decreased in group B,however,which was obviously increased in group C(P0.05).Conclusion The curcumin has protective effects on the kidney of experimental diabetic rats by up-regulating the expression of MMP-2 and down-regulating the expression of TIMP-2 in glomeruli of diabetic rats.