clinical observations of Olanzapine replacement in treatment 60 paotients with schizophrenia

Objective To explore the effect and safety of Olanzapine treatment of schizophrenia. Methods The 60 Schizophrenic patients should accord with the diagnosis of CCMD-3 and with the other medication excluded Olanzapine for 30 days. Furthermore,the patients should have no severe side effects and not good effect needing replacement. So the patients’medication was replaced by Olanzapine 5 ～ 30 mg/day for 8 weeks. And then the patients were assessed with PANSS ,TESS and labor tests. Results Among the 60 patients,almost recovery included 14 cases(23. 33% ),notably improvement was 22 cases(36. 67% ),improvement was 15 cases(25. 00% ),inefficacy was 9 cases(15. 00% ),and the total efficacy rate was 85. 00% . The side effect included 1 case of tiny tremor,6 cases f day sleeping,2 cases of dry mouth,and 1case of snuffle and 1 case of tiny nausea,which were not dealt with. When the dosage exceeded 20 mg/day,1 case of akathisia,5 cases of sinus tachycardia appeared and all the symptoms were alleviated by using propanolol. After 4 weeks,24 case appeared weight gaining (40% ),varying from 2 to 7 kilograms. Conclusions Olanzapine is good for positive,negative and general psychotic syndromes. The common side effects are cholinergic effects,lethargy and weight gaining and so on. Olanzapine is good for replacement to others,and has good safety and compliance.