Clinical Observations of Olanzapine Replacement in Treatment 45 Paotients with Schizophrenia

OBJECTIVE To explore the effect and safety of Olanzapine treatment of schizophrenia.METHODS The 45 schizophrenic patients should accord with the diagnosis of CCMD-3 and with the other medication excluded Olanzapine for 30 days.Furthermore, the patients should have no severe side effects and not good effect needing replacement.So the patients' medication was replaced by Olanzapine 5~20 mg/day for 8 weeks.And then the patients were assessed with PANSS,TESS and labor tests.RESULTS Among the 45 patients,almost recovery included 13 cases(28.89%),notably improvement was 17 cases(37.78%),improvement was 9 cases (36.00%),inefficacy was 6 cases(13.33%),and the total efficacy rate was 86.67%.The side effect included 1 case of tiny tremor,6 cases f day sleeping,3 cases of dry mouth,and lease of snuffle and 1 case of tiny nausea,which were not dealt with.After 4 weeks,16 case appeared weight gaining(35.56%),varying from 2 to6 kilograms.CONCLUSIONS Olanzapine is good for positive, negative and general psychotic syndromes.The common side effects are cholinergic effects,lethargy and weight gaining and so on. Olanzapine is good for replacement to others,and has good safety and compliance.