Security analysis of intensive statins treatment before PCI in patients with non-ST-elevated acute coronary syndrome

Objective To analyze the security of different doses statins treatment before PCI in patients with non ST elevation acute coronary syndrome. Methods Fifteen patients with non-ST-elevation acute coronary artery diseases scheduled for PCI were selected. These patients were randomly divided into two groups: intensive treatment group(7 cases) and conventional treatment group(8 cases). Patients in intensive treatment group were given atorvastatin 80 mg / d for 2 days before PCI,then 40 mg / d for 30 days after PCI,then 20 mg / d for long. Patients in conventional treatment group were given atorvastatin 10- 20 mg orally,every night,from start to finish. For the two groups,before PCI,and 2 d,(30 ± 3)d,(90 ± 7)d,(80 ± 7)d after PCI,the serum level of ALT,TBiL,Cr(except 90,180 days after PCI),CK were detected. Results Only TBiL of 30 days after PCI in intensive statins treatment group was higher than that in convenional treatment group(P = 0. 002),but it was transient. There were no significant differences in other indexes at any time points between the two groups(P 0. 05). Conclusion Intensive statins treatment before PCI in patients with non-ST-elevation acute coronary syndrome is secure.