The clinical effect study of intensive antiplatelet therapy in patients of acute non ST-segment elevation coronary syndrome after PCI

Objective To observe efficacy and safety of different clopidogrel dosage treatment programs on acute non ST-segment elevation coronary syndrome patients after PCI.Methods 506 cases of non ST-segment elevation myocardial infarction patients,who all underwent PCI were included.Patients were randomly divided into the standard group and the intensive treatment group.Patients of standard group received clopidogrel 300 mg after admission then 75 mg/d maintainance.Patients of intensive treatment group received clopidogrel 300 mg after admission then,150 mg/d till 5 days after PCI and 75 mg/d for maintainance.All of the patients had platelet aggregation rate(PA) examination in hospital at admission,24 h after clopidogrel treatment,at the preoperation and 5 days after PCI.All patients do PLT examination at the preoperative and 5 days after PCI.Follow-up of major cardiovascular events and bleeding events were recorded for 30 days.Results The PA of the intensive treatment group were decreased in the preoperation and 5 days after PCI.Compared with the standard group,the PA of the intensive treatment group were decreased in preoperation and 5 days after PCI(t=18.3929,P0.05;t=13.1384,P0.005).During 30 days follow-up,major cardiovascular events of the intensive treatment group were none compared with 4 cases in the standard group.The bleeding events incidence of the two group had no significant difference.Conclusions The intensive antiplatelet therapy can inhibit platelet aggregation rate without increasing the risk of bleeding.