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2010•Unpublished venueRequires access

Influences of Etomidate on the Analgesic and Hypnotic Effects of Isoflurane in Mice

Qian Long

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Abstract

Objective:To observe the influences of etomidate on the analgesic and hypnotic effects of isoflurane.Methods:120 mice were randomly divided into 3 groups for three tests(n=40);and each large group were further divided into 4 small groups(n=10): normal saline group(NS group),etomidate group(E group),isoflurane group(Iso group) and the combination of isoflurane and etomidate group(Iso + E group).Tail-flick latency(TFL) in tail-flick test,writhing times(WTs) in writhing test and sleeping latency(SL),sleeping time(ST),sleeping ratio in hypnotic test were employed to observe the variation of each group.Results:Etomidate prolonged the analgesic period of isoflurane in mice(P0.05) and decreased the WTs(P0.05);shortened the SL(P0.05),prolonged the ST significantly(P0.01) and increased the sleeping ratio.Conclusions:Etomidate can reinforce the analgesic and hypnotic effects of isoflurane in mice.

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Objective:To observe the influences of etomidate on the analgesic and hypnotic effects of isoflurane.Methods:120 mice were randomly divided into 3 groups for three tests(n=40);and each large group were further divided into 4 small groups(n=10): normal saline group(NS group),etomidate group(E group),isoflurane group(Iso group) and the combination of isoflurane and etomidate group(Iso + E group).Tail-flick latency(TFL) in tail-flick test,writhing times(WTs) in writhing test and sleeping latency(SL),sleeping time(ST),sleeping ratio in hypnotic test were employed to observe the variation of each group.Results:Etomidate prolonged the analgesic period of isoflurane in mice(P0.05) and decreased the WTs(P0.05);shortened the SL(P0.05),prolonged the ST significantly(P0.01) and increased the sleeping ratio.Conclusions:Etomidate can reinforce the analgesic and hypnotic effects of isoflurane in mice.

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Available abstract

Objective:To observe the influences of etomidate on the analgesic and hypnotic effects of isoflurane.Methods:120 mice were randomly divided into 3 groups for three tests(n=40);and each large group were further divided into 4 small groups(n=10): normal saline group(NS group),etomidate group(E group),isoflurane group(Iso group) and the combination of isoflurane and etomidate group(Iso + E group).Tail-flick latency(TFL) in tail-flick test,writhing times(WTs) in writhing test and sleeping latency(SL),sleeping time(ST),sleeping ratio in hypnotic test were employed to observe the variation of each group.Results:Etomidate prolonged the analgesic period of isoflurane in mice(P0.05) and decreased the WTs(P0.05);shortened the SL(P0.05),prolonged the ST significantly(P0.01) and increased the sleeping ratio.Conclusions:Etomidate can reinforce the analgesic and hypnotic effects of isoflurane in mice.

Key concepts: Etomidate, Isoflurane, Hypnotic, Analgesic, Anesthesia, Saline, Medicine, Propofol

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