Clinical analysis of 51 cases with nosocomial pulmonary fungal infection in respiratory intensive care unit

Objective:To analyze the morbility,risk factors,etiology,treatment and outcome of nosocomial pulmonary fungal infections in respiratory intensive care unit(RICU).Methods: 51 patients with nosocomial pulmonary fungal infections in RICU between Jan 2003 and Dec 2008 were retrospectively analyzed. Results:All of 51 cases were clinically diagnosed as probable nosocomial pulmonary fungal infections,with the morbidity of 11.78% significantly higher than general wards(1.75%,P0.01).COPD and bacterial pneumonia were the major underlying diseases of respiratory system with a percent of 33.3% and 35.3% respectively,43 patients (84.3%) had risk factors for fungal infections.Compared with general wards,the proportion of aspergillosis was higher in RICU without significant difference(P0.05).The effective rate of antifungal treatment was 82.4% and fluconazol was the most common used antifungal agents.The mortality of fungal infection in RICU was higher than that of general wards but without significant difference(P0.05).Conclusions:The morbidity of nosocomial pulmonary fungal infection in RICU is higher than in general wards.Early and effective treatment is needed in these patients considering the poor prognosis.