Intramuscular olfen-75 dolantin versus tramadol hydrochloride versus olfen-75 in the relief of renal colic

OBJECTIVE To compare the efficacy and adverse effects of intramuscular olfen-75 and intramuscular dolantin,or Tramadol hydrochloride in the relief of acute renal colic.METHODS Randomized study was performed in 108 patients admitted to the emergency room for renal colic.Patients were assigned to treatment with either Olfen-75(A group)75mg or dolantin(B group)50-100mg,or tramadol(C group)100mg,all administered intramuscularly.Pain was self-assessed using a 4-point verbal rating scale(VRS-4)and a Numeric rating scale(NRS)just before drug administration and 15,30,60,120,240,360 and 480 minutes later.RESULTS The 3 groups were similar with regard to baseline characteristics.The percentages of patients who reported an improvement in the VRS at 60 min post-administration(primary variable)at A and B groups versus C group were significant(P=0.001);between A and B groups were no siginificant(P0.05).The NRS score showed a statistically significant improvement in theree groups,but no differences between A and B groups were found.But the time of renal colic relief in A group showed significant(P0.01)longer than B and C groups.Mild to moderate adverse events were reported by 14 frequency of patients receiving Oleen-75 and by 40 frequency of patients receiving dolantin,and by 36 frequency patients receiving tramadol.CONCLUSIONS Olfen-75 was similarly effective in the relief of acute renal colic as dolatin,but better than tramadol hydrochloride,and at the same time,mild to moderate adverse events of Olfen-75 were less than dolantin and tramadol hydrochloride.