The Postoperative Analgesic Effect of Tramadol Hydrochloride on the Patients Undergoing Remifentanil-based Anaesthesia

Objective: To study the analgesic effect of tramadol hydrochloride on the patients undergoing laparoscopic cholecystectomy after remifentanil-based anaesthesia.Method: A total number of ninety ASA Ⅰ-Ⅱ adult patients who underwent the operation of laparoscopic cholecystectomy were divided into three groups randomly.Controlled group(Group C),Tramadol group(Group A)and ketamine group(Group B).Before the end of surgery,the patient of group A was given tramadol hydrochloride 2 mg/kg,group B was given ketamine 0.5 mg/kg,and group C was given 2mL 0.9% natural solution.All patients were inducted by using propofol,remifentanil and rocuronium,and maintained aneasthesia with propofol and remifentanil throughout the operation.In the recovery room,those patients were given tramadol 2mg/kg who felt the moderate pain(VAS score ≥6).VAS score,the time of requiring analgesia by patients and adverse drug reactions such as nausea,vomit and diplopia were recorded for 30min after surgery.Result: There were no significant differece in postoperation recovery time,pharyngeal mask withdrew time,heart rate and blood pressure changes amorg the three groups(P 0.05).At the time of 1 min,10 min,20 min,0.5 hours and 4 hours after patients regaining consciousness,the VAS scores of group A and group B were significantly lower than that of group C(P 0.05),the frequency of patients requiring analgesia in group A and group B were also significantly lower than that in group C(P 0.01),and moreover group A were lower than group B(P = 0.01),the adverse drug reaction showed no significant difference except that the incidence of restlessness of group A and B were significantly lower than that in group C(P 0.01).Conclusion: As well as ketamine,tramadol hydrochloride has significant analgesic effect on patients with postoperative hyperalgesia after remifentanil-based anaesthesia.