Changes and clinical significance of P-selectin and von willebrand factor in patients with ischemic stroke

Objective To study the changes and clinical significance of P-selectin(CD62P),von willebrand factor(VWF)expression in patients with ischemic stroke.Methods Thirty cases of acute ischemic stroke(both acute and convalescence)and 30 normal controls were enrolled in the study,CD62P and VWF expression were detected by ELISA.The correlation between the expression and neurological functional deficit scale was analyzed.Results(1)The expressions of CD62P and VWF in acute phase of ischemic stroke were markedly higher than that in convalescence phase(P0.05)and those in controls(P0.05).The exprtssions of CD62P and VWF expression in convalescence were still higher than those in controls(P0.05).(2)CD62P and VWF expressions were positively related with the scores of neurological functional deficit scale(r=0.837,r=0.632,P0.01).Conclusion High expression of CD62P and VWF may participate in the pathologic process of cerebral ischemic injury and reflect the severity of disease indirectly.