ScholarLens Back to search
2008•Chinese Journal of Difficult and Complicated CasesRequires access

The relationship between lymph node metastasis and expression of VEGF-C and its receptor in colorectal carcinoma

Meng Li

Open publisher page 0 citations

Abstract

Objective To explore the correlation between lymph node metastasis and expression of VEGF-C and its receptor(KDR)in colorectal carcinoma.Methods Retrospectively 74 specimen of colorectal carcinoma,36 of them were identified with lymph node metastasis and 38 of them without.The expression of VEGF-C and KDR was examined by immunohistochemistry in primary mass and metastatic lymph node.Results There was no statistical difference of VEGF-C expression between primary carcinoma and metastatic lymph nodes in metastasis cases(P0.05),while there was statistical difference in non-metastasis cases(P0.01).The similar results could be found in expression of KDR.Conclusion The increase of VEGF-C expression had closely relationship with genic mutation than micro-environment,the size of carcinoma and the density of carcinoma.The expression of VEGF-C and KDR were relatively with lymphatic metastasis in colorectal carcinoma.

About this research paper

What this paper is about

Objective To explore the correlation between lymph node metastasis and expression of VEGF-C and its receptor(KDR)in colorectal carcinoma.Methods Retrospectively 74 specimen of colorectal carcinoma,36 of them were identified with lymph node metastasis and 38 of them without.The expression of VEGF-C and KDR was examined by immunohistochemistry in primary mass and metastatic lymph node.Results There was no statistical difference of VEGF-C expression between primary carcinoma and metastatic lymph nodes in metastasis cases(P0.05),while there was statistical difference in non-metastasis cases(P0.01).The similar results could be found in expression of KDR.Conclusion The increase of VEGF-C expression had closely relationship with genic mutation than micro-environment,the size of carcinoma and the density of carcinoma.The expression of VEGF-C and KDR were relatively with lymphatic metastasis in colorectal carcinoma.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the correlation between lymph node metastasis and expression of VEGF-C and its receptor(KDR)in colorectal carcinoma.Methods Retrospectively 74 specimen of colorectal carcinoma,36 of them were identified with lymph node metastasis and 38 of them without.The expression of VEGF-C and KDR was examined by immunohistochemistry in primary mass and metastatic lymph node.Results There was no statistical difference of VEGF-C expression between primary carcinoma and metastatic lymph nodes in metastasis cases(P0.05),while there was statistical difference in non-metastasis cases(P0.01).The similar results could be found in expression of KDR.Conclusion The increase of VEGF-C expression had closely relationship with genic mutation than micro-environment,the size of carcinoma and the density of carcinoma.The expression of VEGF-C and KDR were relatively with lymphatic metastasis in colorectal carcinoma.

Key concepts: Medicine, Colorectal cancer, Immunohistochemistry, Metastasis, Carcinoma, Lymph node, Lymph, Lymph node metastasis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The relationship between lymph node metastasis and expression of VEGF-C and its receptor in colorectal carcinoma — Research Paper | ScholarLens