Expression of Beclin1 and PTEN Protein and Their Relationship with Clinic Characteristic of Epithelial Ovarian Cancer

Objective To investigate the expression of Beclin1 and PTEN protein in the epithelial ovarian carcinoma and their relationship with clinic characteristic.Methods The expression of Beclin1 and PTEN protein in 25 cases of normal ovary,25 cases of benign ovarian tumor,19 cases of borderline ovarian tumor and 69 cases of epithelial ovarian cancer tissue were detected by immuohistochemical method.Results(1)The high expression of Beclin1 and PTEN was found in normal and benign ovarian tumor tissues.The expression decreased in the borderline ovarian tissues,and was the lowest in the ovarian cancer(P0.05).(2)The expression of Beclin1 and PTEN in stage Ⅰ-Ⅱ,high and middle grade and negative lymph node metastasis epithelial ovarian cancer were higher than that in stage Ⅲ-Ⅳ,low grade,positive lymph node metastasis ovarian cancer(P0.05).Conclusion The expression of Beclin1 and PTEN is down-regulated in the epithelial ovarian cancer.This may play an important role in the initiation and development of ovarian cancer.