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2010•Chinese Journal of RehabilitationRequires access

Effects of Atorvastatin on Vascular Fibrosis and Connective Tissue Growth Factor in Renovascular Hypertensive rats

Chen Zhi-lon

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Abstract

Objective:To investigate the effects of atorvastatin on vascular fibrosis and connective tissue growth factor (CTGF) in renovascular hypertensive (RH) rats. Methods:The following groups of rats were studied: sham group, RH group and atorvastatin (10 mgokg-1od-1)-treated RH group. Systolic blood pressure (SBP) was measured. The mRNA expression of CTGF, FN and ColⅢ was detected by RT-PCR at the 12th week after operation. The expression of CTGF protein was detected by immunohistochemistry. Results: Compared with the normal control group, the mRNA expression of CTGF (P0.01), FN and ColⅢ (P0.05) in RH group was increased in the thoracic aorta, and atorvastatin could significantly inhibit vascular fibrosis and the expression of CTGF (P0.05). Conclusion: Atorvastatin could inhibit the development of vascular fibrosis in RH rats, which was probably related to the decreased expression of CTGF.

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What this paper is about

Objective:To investigate the effects of atorvastatin on vascular fibrosis and connective tissue growth factor (CTGF) in renovascular hypertensive (RH) rats. Methods:The following groups of rats were studied: sham group, RH group and atorvastatin (10 mgokg-1od-1)-treated RH group. Systolic blood pressure (SBP) was measured. The mRNA expression of CTGF, FN and ColⅢ was detected by RT-PCR at the 12th week after operation. The expression of CTGF protein was detected by immunohistochemistry. Results: Compared with the normal control group, the mRNA expression of CTGF (P0.01), FN and ColⅢ (P0.05) in RH group was increased in the thoracic aorta, and atorvastatin could significantly inhibit vascular fibrosis and the expression of CTGF (P0.05). Conclusion: Atorvastatin could inhibit the development of vascular fibrosis in RH rats, which was probably related to the decreased expression of CTGF.

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Available abstract

Objective:To investigate the effects of atorvastatin on vascular fibrosis and connective tissue growth factor (CTGF) in renovascular hypertensive (RH) rats. Methods:The following groups of rats were studied: sham group, RH group and atorvastatin (10 mgokg-1od-1)-treated RH group. Systolic blood pressure (SBP) was measured. The mRNA expression of CTGF, FN and ColⅢ was detected by RT-PCR at the 12th week after operation. The expression of CTGF protein was detected by immunohistochemistry. Results: Compared with the normal control group, the mRNA expression of CTGF (P0.01), FN and ColⅢ (P0.05) in RH group was increased in the thoracic aorta, and atorvastatin could significantly inhibit vascular fibrosis and the expression of CTGF (P0.05). Conclusion: Atorvastatin could inhibit the development of vascular fibrosis in RH rats, which was probably related to the decreased expression of CTGF.

Key concepts: CTGF, Atorvastatin, Connective tissue, Fibrosis, Internal medicine, Medicine, Endocrinology, Growth factor

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Effects of Atorvastatin on Vascular Fibrosis and Connective Tissue Growth Factor in Renovascular Hypertensive rats — Research Paper | ScholarLens