ScholarLens Back to search
2012•Zhongguo xin yao zazhiRequires access

Influence of penetration enhancers on in vitro transdermal permeation of dl-praeruptorin A

Feihong Meng

Open publisher page 1 citations

Abstract

Objective: To study the effect of penetration enhancers on the in vitro transdermal permeation of dl-praeruptorin A(Pd-Ia) through rat skin.Methods: The permeation experiments were evaluated by Franz diffusion cell in excised rat skin.HPLC-UV method was established to determine the concentration of Pd-Ia in receptor compartment.Azone or 1% Azone combined with propylene glycol(PG) as chemical penetration enhancers were applied to study the skin permeation rates of Pd-Ia.Results: 1% Azone alone achieved the highest penetration rate,4.064 μg·cm-2·h-1.1% Azone combined with 15% PG was the best penetration enhancer with the maximal penetration rate of 4.889 μg·cm-2·h-1.Conclusion: Combination of 1% Azone with 15% PG is effective on transdermal permeation of Pd-Ia in vitro,and the combination exerts a synergistic effect.

About this research paper

What this paper is about

Objective: To study the effect of penetration enhancers on the in vitro transdermal permeation of dl-praeruptorin A(Pd-Ia) through rat skin.Methods: The permeation experiments were evaluated by Franz diffusion cell in excised rat skin.HPLC-UV method was established to determine the concentration of Pd-Ia in receptor compartment.Azone or 1% Azone combined with propylene glycol(PG) as chemical penetration enhancers were applied to study the skin permeation rates of Pd-Ia.Results: 1% Azone alone achieved the highest penetration rate,4.064 μg·cm-2·h-1.1% Azone combined with 15% PG was the best penetration enhancer with the maximal penetration rate of 4.889 μg·cm-2·h-1.Conclusion: Combination of 1% Azone with 15% PG is effective on transdermal permeation of Pd-Ia in vitro,and the combination exerts a synergistic effect.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To study the effect of penetration enhancers on the in vitro transdermal permeation of dl-praeruptorin A(Pd-Ia) through rat skin.Methods: The permeation experiments were evaluated by Franz diffusion cell in excised rat skin.HPLC-UV method was established to determine the concentration of Pd-Ia in receptor compartment.Azone or 1% Azone combined with propylene glycol(PG) as chemical penetration enhancers were applied to study the skin permeation rates of Pd-Ia.Results: 1% Azone alone achieved the highest penetration rate,4.064 μg·cm-2·h-1.1% Azone combined with 15% PG was the best penetration enhancer with the maximal penetration rate of 4.889 μg·cm-2·h-1.Conclusion: Combination of 1% Azone with 15% PG is effective on transdermal permeation of Pd-Ia in vitro,and the combination exerts a synergistic effect.

Key concepts: Azone, Permeation, Penetration (warfare), Transdermal, Chemistry, In vitro, Chromatography, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Influence of penetration enhancers on in vitro transdermal permeation of dl-praeruptorin A — Research Paper | ScholarLens