Effect of β-amyloid protein on the neurons of hippocampus in aluminum poisoning model of rats

Objective To study the effect of β-amyloid protein(Aβ) on the neurons of hippocampus in aluminum poisoning model of rats.Methods Based upon the model of aging rats administrated with aluminum chloride by intraperitoneal injection.And hippocampal microinfusion of Aβ,the behaviors of rats were measured by Y-maze and onetrial passive avidance response,and the content of SOD and MDA were measured.Results In the AlCl_3+NS and AlCl_3+Aβ group rats,the spontaneous activities and responses in the open field were significantly decreased,and the abilities of learning-memory were remarkably attenuated,the content of SOD decreased and MDA content increased markedly in hippocampus(P 0.05 or P0.01) compared with control group.Conclusion The result suggested that the combination of aluminum and Aβ could induce the increase of damage by free radical in rat hippocampus and a conspicuous reduction of learning-memory ability in rat.