ScholarLens Back to search
2001•Zhongguo laonianxue zazhiRequires access

The effect of β-amyloid protein on the behavior of aging rats and content of SOD and MDA in hippocampus of aging rats

Qin Hei

Open publisher page 0 citations

Abstract

? Objective To study the effect and mechanism of β amyloid protein(βAP) and D galactose(D gal) on learning and memory in aging rats.Methods The behavior of rats were measured by using open field,Y maze and one trial passive avoidance response and the content of SOD and MDA were measured.Results In the D gal and D gal+βAP group,the spontaneous activities and responses to novel environment on the open field were significantly decreased,and the abilities of learning memory were remarkably attenuated,the content of SOD decreased and MDA content increased markedly in hippocampus compared with control group( P 0 05 or P 0 01).Conclusions The combination of β AP and D gal induces the increased damage by free radical in hippocampus and a significant reduction in learning memory ability of rats. 〔

About this research paper

What this paper is about

? Objective To study the effect and mechanism of β amyloid protein(βAP) and D galactose(D gal) on learning and memory in aging rats.Methods The behavior of rats were measured by using open field,Y maze and one trial passive avoidance response and the content of SOD and MDA were measured.Results In the D gal and D gal+βAP group,the spontaneous activities and responses to novel environment on the open field were significantly decreased,and the abilities of learning memory were remarkably attenuated,the content of SOD decreased and MDA content increased markedly in hippocampus compared with control group( P 0 05 or P 0 01).Conclusions The combination of β AP and D gal induces the increased damage by free radical in hippocampus and a significant reduction in learning memory ability of rats. 〔

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

? Objective To study the effect and mechanism of β amyloid protein(βAP) and D galactose(D gal) on learning and memory in aging rats.Methods The behavior of rats were measured by using open field,Y maze and one trial passive avoidance response and the content of SOD and MDA were measured.Results In the D gal and D gal+βAP group,the spontaneous activities and responses to novel environment on the open field were significantly decreased,and the abilities of learning memory were remarkably attenuated,the content of SOD decreased and MDA content increased markedly in hippocampus compared with control group( P 0 05 or P 0 01).Conclusions The combination of β AP and D gal induces the increased damage by free radical in hippocampus and a significant reduction in learning memory ability of rats. 〔

Key concepts: Hippocampus, Open field, Endocrinology, Internal medicine, Chemistry, Galactose, Amyloid (mycology), Antioxidant

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The effect of β-amyloid protein on the behavior of aging rats and content of SOD and MDA in hippocampus of aging rats — Research Paper | ScholarLens