The clinical value of anti-cyclic citrull inated peptide antibody in patients with rheumatoid arthritis

Objective:To detect anti-cyclic citrullianted peptide (CCP) antibody in patients with rheumatoid arthritis (RA) and explore its clinical value.Methods:Enzyme linked immunosorbent assay (ELISA),indirect immuneofluorescence (IIF),rate nephelometry were used to detect anti-CCP antibodies,Anti-keratin antibodies (AKA) and Rheumatoid factor (RF) in patients with 202 RA,103 non-RA other rheumatic cases and 20 normal donors group.Results:Among 202 patients with RA,167patients showed positive for anti-CCP (82.67%),whereas only 3.83% in 103 non-RA group.The sensitivity and specificity of anti-CCP antibodies were 82.67%,94.17% in RA respectively.The sensitivity and specificity of RF were 86.63%,71.84% in RA respectively.The sensitivity and specificity of AKA were 8.9%,99.03% in RA respectively.Anti-CCP antibodies were more sensitive and specific than RF and AKA for diagnosing RA,although there were correlations among three kinds of antibodies.Conclusion:Detecting anti-CCP antibodies by/ELISA may be a brief,standard and reliable method.Anti-CCP antibodies can be considered as one kind of masker antibody for RA.