The Clinical Value of Anti-Cyclic Citrullinated Peptide Antibody in Patients with Rheumatoid Arthritis

Objective To detect anti-cyclic citrullianted peptide(CCP)antibody in patients with rheumatoid arthritis(RA)and explore its clinical value. Methods Anti-CCP antibodies were examined by an ELISA in 108RA,89 non-RA patients and 78 normal donors. Anti-keratin antibodies(AKA)were detected by indirect immunofluorescence(ⅡF).Rheumatoid factor(RF)was assayed by rate nephelometry method and compared the correlations among the anti-CCP,AKA and RF. Results Among 108 patients with RA,94 patients showed positive for anti-CCP(87.4%),whereas only 8.99 % in 89 non-RA patients. The sensitivity and specificity of anti-CCP antibodies,AKA and RF were 87.4% ,91.01%; 58.33%、82.24%; 81.14%、79.47% in RA respectively. Anti-CCP antibodies are more sensitive and specific than RF and AKA for diagnosing RA,although there were correlations among three kinds of antibodies. Conclusion Detecting anti-CCP antibodies by ELISA may be a brief,standard and reliable method. Anti-CCP antibodies can be considered as one kind of masker antibody for RA.