Clinical value of Down's syndrome screening results analysis in the second trimester of pregnancy

Objective To compare the positive rates of abnormal chromosome karyotype in high risk population of Down's syndrome and 18-trisomy syndrome,and analyze the high risk compositions of 115 cases of chromosome abnormal foetuses in the hospital,so as to improve the analysis level of prenatal screening results and maximize the decrease of birth of fetus with chromosomal abnormality. Methods The prenatal screening results of the 115 pregnant mothers in the middle of pregnancy were retrospectively analyzed in the past 3 years. Results There were significant statistical differences among the positive rates of different abnormal chromosome karyotypes in both two groups of high risk population,which was also found in positive rates of abnormal chromosome karyotypes between the two groups of high risk population. The positive rates of 18-trisomy syndrome and other chromosome abnormalities in 18-trisomy high risk population were higher than those in high risk group of Down's syndrome. It was prompted that there were 93 high risk cases of Down syndrome and 31 high risk cases of 18-trisomy syndrome in 115 abnormal chromosome cases. Conclusion Prenatal screening can prompt the high risk of Down's syndrome and 18-trisomy syndrome,as well as the risk of the abnormality of the other chromosome number and structure.