Analysis the rate of chromosomal abnormality in 2081 cases of Down′s syndrome screening of high risk pregnant amniotic fluid

Objective:To investigate the valule of high risk of Down′s syndrome screening for predicting fetal chromosomal abnormalities at birth. Methods:2081 cases of pregnant women called for chromosome karyotype analysis due to the high-risk of Down′s screening in prenatal diagnosis center in our hospital from January 2010 to March 2014 were reviewed,Summarizing the distribution of various chromosome abnormalities. Result:62 cases were detected chromosome abnormalities in the 2081 cases with high risk of Down′s syndrome screening(the rate was 2.98%),including aneuploidy abnormality 43 cases(2.07%),and 19 cases with chromosomes structure abnormality(0.91%). Conclusion:High risk of Down′s syndrome screening index can be screened including aneuploidy abnormality and chromosome structural abnormality of fetal abnormalities,which may lead to the decrease of chromosomal abnormalities in fetal birth rate.