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2011•Journal of Medical ForumRequires access

Effect of Tanreqing injection on anti-respiratory syncytial virus(RSV,long strain) in vitro

Xiao Min

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Abstract

Objective To explore anti-respiratory syncytial virus(RSV) effect of Chinese medicinal Tanreqing injection.Methods The technique of cell cultuer and MTT with ribavirin as positive concentration-dependent manner.Results The median toxic concentration(TC50) of 3.972 g/L in Hep-2 cell culture.The median effective concentration(EC50)was 0.428 g/L when drug was added 24h before infection,the EC50 was 1.160g/L when drug was added 2 h after virus infection,and it was 1.189 g/L as the drug was added after it mixed with virus 24 h.The therapeutic index(TI)was 9.28,3.42and 3.34 respectively.Conclusions Tanreqing injection has the direct deactivation and blocking effect on RSV.The preventive effect is the most evident with the same concentration in vitro.

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Objective To explore anti-respiratory syncytial virus(RSV) effect of Chinese medicinal Tanreqing injection.Methods The technique of cell cultuer and MTT with ribavirin as positive concentration-dependent manner.Results The median toxic concentration(TC50) of 3.972 g/L in Hep-2 cell culture.The median effective concentration(EC50)was 0.428 g/L when drug was added 24h before infection,the EC50 was 1.160g/L when drug was added 2 h after virus infection,and it was 1.189 g/L as the drug was added after it mixed with virus 24 h.The therapeutic index(TI)was 9.28,3.42and 3.34 respectively.Conclusions Tanreqing injection has the direct deactivation and blocking effect on RSV.The preventive effect is the most evident with the same concentration in vitro.

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Available abstract

Objective To explore anti-respiratory syncytial virus(RSV) effect of Chinese medicinal Tanreqing injection.Methods The technique of cell cultuer and MTT with ribavirin as positive concentration-dependent manner.Results The median toxic concentration(TC50) of 3.972 g/L in Hep-2 cell culture.The median effective concentration(EC50)was 0.428 g/L when drug was added 24h before infection,the EC50 was 1.160g/L when drug was added 2 h after virus infection,and it was 1.189 g/L as the drug was added after it mixed with virus 24 h.The therapeutic index(TI)was 9.28,3.42and 3.34 respectively.Conclusions Tanreqing injection has the direct deactivation and blocking effect on RSV.The preventive effect is the most evident with the same concentration in vitro.

Key concepts: Ribavirin, Virus, In vitro, EC50, Respiratory system, Strain (injury), Drug, MTT assay

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