Application of Thinprep cytologic test in cervical pathological changes

Objective To investigate the reliability of Thinprep cytologic test(TCT) technique and the Bethesda System(TBS) project in screening of cervical pathological changes.Methods 4629 cervical liquid based cytology samples were collected in this study and diagnosed by TBS project.170 cytology positive cases were compared by colposcopical examination and biopsy and their age of onset were analysed.Results By TCT technique,100%(4/4) squamous carcinoma of the cervix(SCC),94%(47/50) high grade squamous intraepithelial lesion(HSIL),78.8%(41/52) low grade squamous intraepithelial lesion(LSIL) were detected.Chi square test displayed the diagnosis coincidence of HSIL greater than that of LSIL significantly among liquid based cytology,colposcopical biopsy and pathologic histology(P0.05).The age distribution of cytology positive cases always betided in 25-50 age stage,especially in 35-40 age stage,incidence was topmost,and reached up to 30.59%.Conclusion The TCT technique and TBS project have satisfactory applicability for screening cervical pathological changes,and have high sensitive for cervical intraepithelial neoplasia(CIN),especially for HSIL pathological changes and grades above it.It is necessary for women of 25-50 age stage to screen by TCT regularly,emphasis on 35-40 age stage.