The Relation Between Serum Uric Acid, Bilirubin, Fibrinogen and the Severity of Coronary Artery Disease in Patients with Acute Coronary Syndromes

Objective To investigate the relationship between serum uric acid(SUA) , bilirubin(Bil), fibrinogen(FIB) and the severity of coronary heart disease (CHD) in patients with acute coronary syndromes(ACS). Methods One hundred thirty-six patients with ACS were divided into three groups: group A patients with STEMI(n=42); group B patients with NSTEMI(n=46); group C patients with UAP(n=48), 45 normal subjects(group D) served as control. The level of SUA ,TBil and FIB were determined. Results The levels of SUA and FIB in patients with ACS were (374.0±26. 5)μmol/L and (4.35±1.32)g/L, significantly higher than that of control group (258.6±18. 4)μmol/L and (2.26±0.82)g/L(P0.01), The level of TBil in patients with ACS (9.64±3. 24)μmol/L was significantly lower than that of control group (14. 38±3. 62)μmol/L (P0.01). The levels of SUA and FIB positively and the level of Bil negatively related with severity of CHD (P0.01) . Conclusion The levels of elevated SUA and FIB, reduced Bil are closely related with ACS and the sererity of CHD.