Pharmacokinetics of Omeprazole Enteric-coated Tablets in Healthy Volunteers

OBJECTIVE: To study the pharmacokinetics of omeprazole in healthy volunteers.METHODS: 10 healthy volunteers(5 females and 5 males) were given a single oral dose(40 mg) of omeprazole tablets.Venous blood samples were collected at different time and subjected to sample treatment before the HPLC determination of the concentration of omeprazole in plasma samples.The parameters were treated using DAS 2.0 pharmacokinetics software and analyzed using SPSS 11.5 software.RESULTS: Themain pharmacokinetic parameters of omeprazole were as follows: Cmax(760.49±581.232)μg·L-1;tmax(2.7±0.823)h;t1/2(1.601±1.282)h;AUC0～12(1 437.61±798.045) μg·h·L-1;AUC0～∞(1 470.09±769.475)μg·h·L-1,which were in line with those reported in literature and of no statistical significance between different sex.CONCLUSION: The method adopted in our study can be used for the pharmacokinetic study of omeprazole.