Prenatal diagnosis in 311 cases of mid-gestation women

Objective: By analizing karyotype with amniotic cavity in mid-gestation women,to explore clinical risk factors of fetal chromosomal abnormalities and improve the understanding of clinical physicians to the prenatal diagnosis indication of karyotype analysis in amniotic fluid.Methods:311 cases women with 16 ～ 30 pregnant weeks undergo amniocentesis monitored by B-orientation.extract amniotic fluid to culture,and performed the G-banding staining for karyotype analysis.Results:13 cases of chromosomal abnormalities were diagnozied,accounting for 4.18%.Among them,5 cases in pregnant woman or her spouse(5 / 6),6 cases in advanced-age pregnant women(4 / 161),1 case in the women with a reproductive history of 21-or 18 trisomy(1 / 30),2 cases in women under 35 years old and with a history of high risk of Down syndrome(2 / 87),1 case in women with a reproductive history of deformed children.No cases were found in women with positive results of ultrasound soft targets and neither in volunteers without prenatal diagnosis indications.Conclusions: It′s effictive for diagnozed fetal chromosomal disease using amniotic fluid sample to analizing chromosome.The high risks for fetal chromosomal abnormalities include the spouses with chromosomal abnormalities,advanced age pregnant woman,hish-risk woman with Down syndrome,a reproductive history of aneuploid children and deformed children,and positive results of ultrasound soft targets.It′s important to pay highly attention to these risks.