Analysis of fetal chromosome karyotpye with three indications

Objective Summarize and analyze the fetal chromosome karyotype with three prenatal diagnosis indications,provide reference for reasonable actualizing invasive prenatal diagnosis technique.Methods All pregnant women are accepted amniocentesis or percutaneous umbilical blood sampling,among these women 531 pregnant women who serum screening show high risks,310 pregnant women whose age is or over 35 years,30 pregnant women whose fetal color Doppler imaging show abnormalities.Amniotic fluid cells or umbilical cells are cultured,fetal chromosome karyotpyes are analyzed by G band staining technique.Results 27 abnormal karyotpyes are found.There are 15 chromosomal abnormalities in the pregnant women who serum screening show high risks,9 chromosomal abnormalities in the pregnant women whose age is or over 35 years,3 chromosomal abnormalities in the pregnant women whose fetal color Doppler imaging show abnormalities,ratio of chromosomal abnormality is receptively 2.8%,2.9% and 10%.Ratio of chromosomal abnormality in the three group is markedly higher than general people(P0.01),there is no statistical difference between each other(P0.05).Conclusion The three group pregnant women are advised fetal chromosomal examination to avoid the born of children with chromosomal diseases.