The result analysis of prenatal screening for Down syndrome in 3320 mid-pregnancy women

Objective To investigate the application of prenatal screening for Down syndrome(DS),trisomy 18 syndrome and neural tube deformity(NTD) by detecting serum AFP,free β-hCG(f-βhCG) and free estriol in pregnant women(14-20 weeks).Methods Serum AFP,f-βhCG and free estriol concentrations in pregnant women(14-20 weeks) were dectected based on the principal of chemiluminescence.Results were analysed by a computer software from Shanghai Tcsoft company for the risk of pregnant women of fetal Down syndrome,trisomy 13 syndrome and neural tube deformity combining with maternal age and gestational age.Results Among the 3 320 pregnant women,155 cases(4.67%) were at high risk for DS and 25 cases were diagnosed by amniocentesis;27 cases(0.81%) were at high risk for trisomy 18 syndrome;57 cases(1.72%) were found at high risk of prenatal NTD and 9 cases were diagnosed by ultrasonic inspection.Conclusion Prenatal screening is a effective means of prediction severe congenital deformity,which can reduce the birth rate of DS and the incidence rate of invasive antenatal examination.