Dynamic changes of clinical features and pathological lesions in children with IgA nephropathy:analysis of repeat renal biopsy in five cases

Objectives To explore the dynamic changes of clinical features and pathological lesions in children with IgA nephropathy. Methods Clinical and pathological data of five children with IgA nephropathy were collected before and after each renal biopsy. Results Among 5 cases,4 children were biopsied twice, 1 child had 3 times. Basic clinical manifestations of 5 cases were persistent microscopic hematuria or intermittent gross hematuria with varied levels of proteinuria and decreased renal function. The basic renal pathology was mesangial proliferation. Repeated renal biopsies showed pathological progression. Conclusions Clinical features and renal pathological changes of IgA nephropathy were highly variable between cases. When severe relapse occurs,a repeat renal biopsy should be performed to provide information for further treatment. The indication for repeat renal biopsy was discussed.