Analysis of Drug Resistance of Common Clinical Pathogens in Our Hospital during 2009-2011

OBJECTIVE: To analyze the drug resistance of the main pathogens in our hospital, and to provide reference for use of antimicrobial agents. METHODS: Drug resistance of clinical pathogens in our hospital during 2009-2011 was retrospectively analyzed. RESULTS: Among 8 898 strains of isolated pathogens, Gram-negative bacteria accounted for 59.0%, Gram-positive bacteria accounted for 25.6% and fungi accounted for 15.4%. Top 6 pathogens were Escherichia coli (17.6%), Candida albicans (10.5%), Klebsiella pneumoniae (10.4%), Staphylococcus aureus (7.7%), Acinetobacter bauman (6.8%), Pseudomonas aeruginosu (5.9%). Gram-negative bacteria were mostly sensitive to imipenem, amikacin, cefepime, aztreonam, and Gram-negative bacteria were highly resistant to ampicillin and cefazolin; Gram-positive bacteria were mostly sensitive to vancomycin and chloramphenicol; and Candida albicans were mostly sensitive to flucytosine, voriconazole, flaconazole. CONCLUSION: We should enhance surveillance of drugs resistance of pathogens. Antimicrobials should be used rationally on the basis of drug susceptibility test to prevent or delay the emergence of drug-resistant bacteria.