CORRELATION BETWEEN INCREASED HIGH-SENSITIVITY C-REACTIVE PROTEIN COUNT AND POOR PROGNOSIS IN ACUTE MYOCARDIAL INFARCTION PATIENTS TREATED WITH PERCUTANEOUS CORONARY INTERVENTION

[Objective]To explore the relationship between high-sensitivity C-reactive protein(hs-CRP)and the prognosis of patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).[Methods]The study comprised 100 consecutive patients with first attack of AMI.They underwent primary PCI within 12 hours after the onset of chest pain.According to their serum hs-CRP level,these patients were divided into three groups:A Group(hs-CRP﹤3mg/L,n = 18),B Group(3mg/L≤hs-CRP﹤10mg/L,n = 32)and C Group(hs-CRP﹥10mg/L,n = 50).The incidence of major adverse cardiac events(MACE)within 180 postoperative days was followed.[Results]There was significant difference in the serum hs-CRP levels,Left ventricular ejection fraction,hypertension,left anterior descending coronary atery and anterior wall(P﹤0.05).Follow-up for 180 days showed that there was significant difference in the incidence of heart failure within 30 days or 180 days and revascularization rate within 180 days(P﹤0.05).Binary logistic analysis showed that when hs-CRP increased 1 mg/L,the risk of MACE during hospitalization and within 30 days increased 2.4(OR=2.42,P = 0.045)and 2.2(OR=2.187,P = 0.042)folds respectively,the risk of heart failure within 30 days increased 2.6(OR=2.565,P = 0.043)folds.[Conclusion]Increased hs-CRP measured after the primary PCI may be the independent predictive factor of MACE for the AMI patients during hospitalization and within 30 days.It has a stronger predictive value,especially for the incidence of heart failure within 30 days.