Relation between high-sensitivity C-reactive protein levels and prognosis in patients treated with primary percutaneous coronary intervention after acute myocardial infarction

AIM: To study the relationship between high-sensitivity C-reactive protein(hs-CRP) levels and prognosis in patients treated with primary percutaneous coronary intervention(PCI) after acute myocardial infarction(AMI).METHODS: Two hundred and fifteen patients treated with primary PCI after AMI from January 2007 to January 2011 were reviewed and their plasma hs-CRP levels were studied.Plasma hs-CRP concentrations were compared between patients who had a cardiovascular(CV) event and those without.Patients were divided into different groups according to their plasma hs-CRP concentration,and the CV event incidences were compared between groups.RESULTS: A significant difference was found in hs-CRP levels between patients with a CV event and patients without(10±4) mg/L vs.(6±5) mg/L,P0.05).CV event incidences in various hs-CRP level groups were,respectively,hs-CRP 0-3 mg/L 23%,hs-CRP 3-6 mg/L 24%,hs-CRP 6-9 mg/L 47%,hs-CRP 9-12 mg/L 52%,and hs-CRP 12-15 mg/L 70%.Logistic regression analysis showed that the hs-CRP level was significantly related to the incidence of CV event,after correction for gender and age.CONCLUSION: hs-CRP is a prognostic factor in patients treated with primary PCI after AMI,the higher the hs-CRP,the higher the rate of CV event.