Evaluation on the effect of Gatifloxacin therapy in lower respiratory tract acuteinfections

Objective To evaluate the clinical efficacy and safety in a randomized controlled clinical study on Gatifloxacin and Levofloxacin,Cipofloxacin treatment of lower respiratory tract acute infections.Methods Thirty-five patients were treated with 200mg of Gatifloxacin twice daily intravenously;36 patients were treated with 200mg of Levofloxacin twice daily intravenously;32 patients in the Cipofloxacin group were treated with 200mg of Cipofloxacin twice daily intravenously.The courses of treatment were 7～14 days in all groups.Results The cure and effective rates of the Gatifloxacin and Levofloxacin groups were 77.14%、 72.22% and 91.43%、 77.78%(P 0.05),respectively.The cure and effective rates of the Gatifloxacin and Cipofloxacin groups were 77.14%、 53.13% and 91.43%、 65.63%(P 0.05) ,respectively.Bacterial eradication rates of the Gatifloxacin and Levofloxacin groups were 87.88% and 85.29%(P 0.05).Bacterial eradication rates of the Gatifloxacin and Cipofloxacin groups were 87.88% and 65.62%(P 0.05).Conclusions The results suggest that the domestic Gatifloxacin has characteristics with broad spectrum,powerful antibacterial activity and light adverse drugs reaction.Furthermore its efficacy is higher than Cipofloxacin.It can be used to treat lower respiratory tract acute infections safely and effectively.It has comparatively high value of clinical application.