Evaluation of Segregation Ratio and Hereditability of Esophageal Cancer,Gastric Cancer, Liver Cancer in Taixing County

Objective To study the effect of genetic factors on the occurrence of esophageal cancer,gastric cancer and liver cancer.Methods A genetic epidemiological case-control study with 489 pedigrees(esophageal cancer 132, gastric cancer 79, liver cancer 80 and 198 controls) was carried out to estimate the segregation ratio and hereditability (h 2) of esophageal cancer,gastric cancer and liver cancer by the methods of Li-Mantel-Gart and Falconer, respectively.Results The segregation ratio of esophageal cancer, gastric cancer and liver cancer was 0.0839, 0.1206 , 0.1271 respectively.These results were significantly lower than 0.25, and the genetic model belonged to polnged to polygenetic.The h 2 of esophageal cancer, gastric cancer and liver cancer was 18.84%(22.6% for male, 14.69% for female),21.42% (18.23% for male and 31.53% for female),35 74%(30.56% for male, 54.90% for female) respectively.Conclusions The genetic factor is one of the risks for esophageal cancer, gastric cancer and liver cancer, but not a main risk.